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Versus biomimetic cosmetic peptides (matrixyl, argireline, acetyl hexapeptide): these peptides are protein fragments with targeted activity (calcium neurotransmission modulation for argireline, matrix stimulation for matrixyl)

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TB-500 works systemically and thus does not need to be administered to a specific target

then in the above-mentioned resin, add DIEA, DIC or DMAP, Fmoc-Val-OH, react at 10-50C for 0.5-5 hours, then add blocking reagent methanol, benzoyl chloride or pyridine and react at 10-50C for 0.2-3 hours, resin with isopropanol, N,N-di Methylformamide washes to obtain Fmoc-Val-resin

This minimizes blockage of the nasal membrane and also optimizes absorption